CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Nicotine triggers initiation and progression of K-Ras driven pancreatic ductal adenocarcinoma via acinar cell de-differentiation
DOI 10.1055/s-0034-1386182
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Autor:innenPC Hermann, P Sancho, P Michl, T Gress, R De Pascual, L Gandia, M Canamero, C Guerra, M Barbacid, A Aicher, P Martinelli, FX Real, B Sainz Jr, C Heeschen
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Smoking has been identified as a leading risk factor for pancreatic ductal adenocarcinoma. Nicotine is a key active ingredient of tobacco smoke and replacement products, and while nicotine does not have intrinsic carcinogenic properties, we hypothesized that nicotine perpetuates oncogenic transformation of the pancreas by alternative mechanisms. Methods & Results: Using Elastase-K-RasG12V and PDX1-K-RasG…
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Zitierempfehlung
PC Hermann, P Sancho, P Michl, T Gress, R De Pascual, L Gandia, M Canamero, C Guerra, M Barbacid, A Aicher, P Martinelli, FX Real, B Sainz Jr, C Heeschen (2014) Nicotine triggers initiation and progression of K-Ras driven pancreatic ductal adenocarcinoma via acinar cell de-differentiation. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0034-1386182
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