CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
DZNep may directly target putative cancer stem cells in biliary tract cancer cells by inhibition of PRC2
DOI 10.1055/s-0034-1386189
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Autor:innenC Mayr, A Wagner, A Stöcklinger, M Jakab, R Illig, M Pichler, F Berr, D Neureiter, T Kiesslich
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: The Polycomb Repressive Complex 2 (PRC2) silences genes via trimethylation of histone 3 at lysine 27 (H3K27me3). This type of epigenetic silencing represents one mechanism of malignant cells to gain and maintain stem cell-like status. It was shown that 3-Deazaneplanocin-A (DZNep), an S-adenosyl-L-homocysteine hydrolase inhibitor, is able to disturb the PRC2 complex and to reduce H3K27me mediated gene s…
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Zitierempfehlung
C Mayr, A Wagner, A Stöcklinger, M Jakab, R Illig, M Pichler, F Berr, D Neureiter, T Kiesslich (2014) DZNep may directly target putative cancer stem cells in biliary tract cancer cells by inhibition of PRC2. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0034-1386189
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