CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
TRK-antagonist inhibits PanIN progression and cancer in an inflammatory PDAC mouse model
DOI 10.1055/s-0034-1386439
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Autor:innenBW Renz, CB Westphalen, Y Hayakawa, A Kleepies, J Werner, H Remotti, KP Olive, TC Wang
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2014
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: Activation of nerve growth factor neurotrophic tyrosine kinase receptor signaling leads to enhanced proliferation of pancreatic cancer (PDAC) cells. Aim: The aim of this study was to investigate the effect of an experimental pan-TRK receptor tyrosine kinase inhibitor on proliferation of human and murine PDAC cells in vitro and on the progression of PanIN lesions and cancer in the PDX-Cre/LSL-KRASG12D (…
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Zitierempfehlung
BW Renz, CB Westphalen, Y Hayakawa, A Kleepies, J Werner, H Remotti, KP Olive, TC Wang (2014) TRK-antagonist inhibits PanIN progression and cancer in an inflammatory PDAC mouse model. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0034-1386439
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