CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Targeting RIG-I with 5'ppp-modified RNA for immunotherapy of hepatocellular carcinoma (HCC)
DOI 10.1055/s-0034-1386661
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Autor:innenL Posselt, I Lazic, A Funk, S Kirchleitner, S Schievenbusch, T Adunka, S Endres, P Düwell, S Rothenfusser, M Schnurr
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: HCC is the most common primary malignant type of liver cancer. Median survival for patients with advanced tumors is less than one year. Novel treatment options are urgently needed. The cytosolic helicase retinoic acid-inducible gene I (RIG-I) is an immune receptor for viral 5'-triphosphat-RNA (ppp-RNA) and its activation leads to innate and adaptive immunity via type I IFN and proinflammatory cytokines.…
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Zitierempfehlung
L Posselt, I Lazic, A Funk, S Kirchleitner, S Schievenbusch, T Adunka, S Endres, P Düwell, S Rothenfusser, M Schnurr (2014) Targeting RIG-I with 5'ppp-modified RNA for immunotherapy of hepatocellular carcinoma (HCC). Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-0034-1386661
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