CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Antiproliferative and proapoptotic effect of the MLK/JNK inhibitor CEP-1347 in hepatocellular carcinoma
DOI 10.1055/s-0034-1386666
Bibliografische Angaben
Nachweis in CareLit
Autor:innenEN De Toni, S Lu, J Liebl, A Rizzani, B Göke, E Gallmeier, AM Vollmar, AL Gerbes
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Sorafenib is the only systemic agent approved for the therapy of hepatocellular carcinoma (HCC). However, in spite of its efficacy, the investigation of alternative therapeutic targets is urgently required. JNK is overexpressed in the majority of HCC and chemical induction of HCC is prevented by JNK inhibition. Notably, expression of JNK was recently shown to predict a poor response to sorafenib. Neverth…
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Zitierempfehlung
EN De Toni, S Lu, J Liebl, A Rizzani, B Göke, E Gallmeier, AM Vollmar, AL Gerbes (2014) Antiproliferative and proapoptotic effect of the MLK/JNK inhibitor CEP-1347 in hepatocellular carcinoma. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-0034-1386666
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