CareLit · DOI-Nachweis · Geburtshilfe und Frauenheilkunde
Endoxifen and fulvestrant regulate gene expression of estrogen receptor alpha and its co-activators DEADbox5 and 17
DOI 10.1055/s-0034-1388346
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Hirschfeld, V Neumann, M Jäger, T Erbes, E Stickeler
ZeitschriftGeburtshilfe und Frauenheilkunde
Ausgabe09/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Application of anti-estrogens remains a standard therapy in ERα -positive breast cancer. Endoxifen acts as a selective receptor down-modulator of ERα function, while fulvestrant acts as a selective receptor down-regulator via an increased ERα inhibition and degradation. RNA helicases p68 (DDX5) and p72 (DDX17) act as co-activators of ERα. DDX17 expression correlates with decreased Her2/neu levels, extend…
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Zitierempfehlung
M Hirschfeld, V Neumann, M Jäger, T Erbes, E Stickeler (2014) Endoxifen and fulvestrant regulate gene expression of estrogen receptor alpha and its co-activators DEADbox5 and 17. Geburtshilfe und Frauenheilkunde (09). https://doi.org/10.1055/s-0034-1388346
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