CareLit · DOI-Nachweis · Geburtshilfe und Frauenheilkunde
CD47 antibody blockade as novel therapy for ovarian and breast cancer
DOI 10.1055/s-0034-1388418
Bibliografische Angaben
Nachweis in CareLit
Autor:innenAK Volkmer, SB Willingham, JP Volkmer, SR Tseng, PD Ho, BI Sikic, R Majeti, IL Weissman
ZeitschriftGeburtshilfe und Frauenheilkunde
Ausgabe09/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: We have identified CD47 as a “don't eat me” signal expressed by cancer cells to escape elimination by the innate immune system. Upon binding to its receptor SIRPalpha on macrophages, CD47 initiates an inhibitory signal that blocks phagocytosis. We have developed a humanized anti-CD47 antibody, Hu5F9-G4 and tested its therapeutic efficacy on ovarian cancer (OC) and breast cancer (BC) in preclinical mode…
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Zitierempfehlung
AK Volkmer, SB Willingham, JP Volkmer, SR Tseng, PD Ho, BI Sikic, R Majeti, IL Weissman (2014) CD47 antibody blockade as novel therapy for ovarian and breast cancer. Geburtshilfe und Frauenheilkunde (09). https://doi.org/10.1055/s-0034-1388418
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