CareLit · DOI-Nachweis · Geburtshilfe und Frauenheilkunde
Specific inhbitor of ERK 1/2 AEZS-131: anticancer activity in models of human cancers with and without overactivation of ERK 1/2
DOI 10.1055/s-0034-1388478
Bibliografische Angaben
Nachweis in CareLit
Autor:innenJB Engel, S Meyer, J Dietl, B Kwok, O Ortmann, A Hönig, J Hahne
ZeitschriftGeburtshilfe und Frauenheilkunde
Ausgabe09/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Purpose: The RAS/RAF/MEK/ERK pathway is activated in more than 30% of human cancers, mostly via mutation in K-Ras oncogene and also via mutations in BRAF. Although various MEK-inhibitors have been developed, acquired resistance to MEK-inhibitors is a major problem. We investigate specific ERK inhibitor AEZS-131 in a panel of human cancers with and without mutations in the MAPK-pathway. Methods: The ability of AEZS 1…
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Zitierempfehlung
JB Engel, S Meyer, J Dietl, B Kwok, O Ortmann, A Hönig, J Hahne (2014) Specific inhbitor of ERK 1/2 AEZS-131: anticancer activity in models of human cancers with and without overactivation of ERK 1/2. Geburtshilfe und Frauenheilkunde (09). https://doi.org/10.1055/s-0034-1388478
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