CareLit · DOI-Nachweis · Geburtshilfe und Frauenheilkunde
Knockdown of TRAIL-R2 in breast cancer cells impairs bone metastases formation in a preclinical mouse model
DOI 10.1055/s-0034-1388555
Bibliografische Angaben
Nachweis in CareLit
Autor:innenT Heilmann, H Fritsche, R Towers, G Campbell, M Rauner, C Hauser, S Tiwari, W Jonat, C Schem, H Kalthoff, A Trauzold
ZeitschriftGeburtshilfe und Frauenheilkunde
Ausgabe09/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Plasma-membrane localized death receptors TRAIL-R1/R2 induce apoptosis and pro-inflammatory responses when crosslinked by their ligand TRAIL. In its nuclear localization TRAIL-R2 promotes cell proliferation by regulating the maturation of miRNA let-7. Interestingly, overexpression of TRAIL-R2 has been correlated with worse prognosis for patients with breast cancer, which is known to frequently metastas…
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Zitierempfehlung
T Heilmann, H Fritsche, R Towers, G Campbell, M Rauner, C Hauser, S Tiwari, W Jonat, C Schem, H Kalthoff, A Trauzold (2014) Knockdown of TRAIL-R2 in breast cancer cells impairs bone metastases formation in a preclinical mouse model. Geburtshilfe und Frauenheilkunde (09). https://doi.org/10.1055/s-0034-1388555
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