CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
HMGB1 inflammosome activity modulates HIF-1α in a rat model of thioacetamide (TAA)-induced chronic liver damage and cholangiocarcinoma development
DOI 10.1055/s-0034-1397065
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Autor:innenS Ahmad, F Moriconi
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2015
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Background: HIF-1α and HIF-2α have been identified as key mediators of angiogenesis, inflammation, and metabolism and can activate simultaneously distinct target genes with different functions regarding the regulation of hypoxia-related-genes. Methods: Male Wistar rats and TLR-4-/- mice were administrated thioacetamide (TAA) in drinking water up to 20 weeks and sacrificed at 4, 8, 12, 16, 20 weeks. Expression of HIF…
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Zitierempfehlung
S Ahmad, F Moriconi (2015) HMGB1 inflammosome activity modulates HIF-1α in a rat model of thioacetamide (TAA)-induced chronic liver damage and cholangiocarcinoma development. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0034-1397065
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