CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Promoter regulation of the miR-29a/b1 gene by transforming growth factor-β in hepatic stellate cells and in hepatoma cells
DOI 10.1055/s-0034-1397082
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Autor:innenJ Huang, W Amer, HP Dienes, R Büttner, M Odenthal
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2015
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: The members of the miR-29 family, targeting genes involved in apoptosis and gene methylation, are downregulated during hepatocarcinogenesis. Furthermore, in hepatic stellate cells (HSC) they inhibit extracellular matrix formation and are markedly reduced during fibrogenesis and after exposure to TGF-β. Since in both, liver fibrogenesis and carcinogenesis, TGF-β is a central mediator, we studied miR-29…
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Zitierempfehlung
J Huang, W Amer, HP Dienes, R Büttner, M Odenthal (2015) Promoter regulation of the miR-29a/b1 gene by transforming growth factor-β in hepatic stellate cells and in hepatoma cells. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0034-1397082
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