CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Specific Endoglin deletion in primary mouse hepatic stellate cells shows a modulation of TGF-b signaling pathways, aggravating liver fibrosis
DOI 10.1055/s-0034-1397086
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Autor:innenM Alsamman, V Sterzer, C Trautwein, D Scholten
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2015
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Background: Hepatic stellate cells (HSCs) are the major source for extracellular matrix (ECM) production in liver fibrosis. TGF-beta and its auxiliary receptor endoglin (ENG, S- and L-Endoglin splicing variants), which is expressed on HSCs, are important cytokines, mediating cellular responses in liver injury. This study analyzes the role of specific Endoglin deletion in primary mice HSCs using Cre-LoxP genetic reco…
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Zitierempfehlung
M Alsamman, V Sterzer, C Trautwein, D Scholten (2015) Specific Endoglin deletion in primary mouse hepatic stellate cells shows a modulation of TGF-b signaling pathways, aggravating liver fibrosis. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0034-1397086
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