CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Lack of hepatic keap-1 ameliorates steatosis through a negative LXR modulation without altering the innate immune response in a diet-induced model of nonalcoholic steato-hepatitis
DOI 10.1055/s-0034-1397123
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Autor:innenP Ramadori, H Drescher, F Schumacher, S Erschfeld, A Fragoulis, C Wruck, C Trautwein, D Kroy, K Streetz
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Although the generation of reactive oxygen species (ROS) in response to triglyceride accumulation has been classically proposed as a possible “second hit” enabling the progression from simple steatosis to NASH, so far, functional studies failed to demonstrate an indispensable role for oxidative stress in this process. Methods: Hepatocyte-specific keap-1 knockout mice (Keap1Δhepa), over expressing the ant…
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Zitierempfehlung
P Ramadori, H Drescher, F Schumacher, S Erschfeld, A Fragoulis, C Wruck, C Trautwein, D Kroy, K Streetz (2015) Lack of hepatic keap-1 ameliorates steatosis through a negative LXR modulation without altering the innate immune response in a diet-induced model of nonalcoholic steato-hepatitis. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0034-1397123
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