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Endocytosis of the signal transducing receptor gp130 as mechanism to fine-tune IL-6 responses

HM Hermanns, C Mais, S Walter, A Geier · Zeitschrift für Gastroenterologie · Ausgabe 01/2015

DOI 10.1055/s-0034-1397132

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Autor:innenHM Hermanns, C Mais, S Walter, A Geier
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2015
Jahrgang / SeitenNicht angegeben

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Background and aims: The restriction of cytokine signalling in strength and duration is of fundamental importance to limit inflammation. We identified a cross-talk mediated endocytosis by which pro-inflammatory stimuli can influence the responsiveness of liver cells for cytokines of the IL-6 family. Methods: HepG2 hepatoma cells were treated with the pro-inflammatory cytokine IL-1β for different periods of time. IL-…

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HM Hermanns, C Mais, S Walter, A Geier (2015) Endocytosis of the signal transducing receptor gp130 as mechanism to fine-tune IL-6 responses. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0034-1397132

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