CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Experimental validation of the predicted TGR5 binding mode model
DOI 10.1055/s-0034-1397135
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Autor:innenL Spomer, CGW Gertzen, D Häussinger, H Gohlke, V Keitel
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: TGR5 (Gpbar-1) is a G-protein coupled, membrane-bound bile acid receptor, which is expressed in many human tissues. In the liver TGR5 mediated anti-inflammatory, choleretic and anti-apoptotic effects. Furthermore, the receptor has been linked to bile acid and glucose homeostasis, energy expenditure and inflammatory pathways. Thus, it is conceivable that TGR5 agonists can mediate protective effects in v…
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Zitierempfehlung
L Spomer, CGW Gertzen, D Häussinger, H Gohlke, V Keitel (2015) Experimental validation of the predicted TGR5 binding mode model. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0034-1397135
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