CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Lysophosphatidylcholine (LPC) as central player for hepatic fat accumulation and inflammation: implication for the pathogenesis of NASH
DOI 10.1055/s-0034-1397141
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Autor:innenWR Stremmel, S Staffer, A Wannhoff, A Pathil-Warth, W Chamulitrat
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: In NASH the intracellular ratio of phosphatidylcholine (PC): lysophosphatidylcholine (LPC) is decreased due to activation of the membrane localized phospholipase A2 (iPLA2ß). Aim: Evaluation of LPC levels in development and reversal of hepatic fat accumulation and inflammation. Methods: In HepG2 cells the bile acid-phospholipid conjugate ursodeoxycholate-lysophosphatidylethanolamide (UDCA-LPE) as iPLA2ß…
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Zitierempfehlung
WR Stremmel, S Staffer, A Wannhoff, A Pathil-Warth, W Chamulitrat (2015) Lysophosphatidylcholine (LPC) as central player for hepatic fat accumulation and inflammation: implication for the pathogenesis of NASH. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0034-1397141
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