CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Retinoic acid amplifies the FXR-dependent FGF19 gene expression in human enterocyte-like HT-29 cells by a bi-phasic mechanism
DOI 10.1055/s-0034-1397147
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Nachweis in CareLit
Autor:innenD Jahn, D Sutor, HM Hermanns, J Schmitt, A Geier
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and aims: The intestine-derived hormone Fibroblast Growth Factor 19 (FGF19) and its mouse ortholog Ffg15 are key regulators of bile acid synthesis and energy metabolism. FGF15/19 expression is induced by bile acid-mediated activation of FXR. Moreover, vitamin A (VA) has been shown to activate Fgf15 in an RXR/FXR-dependent manner in mice. Whether VA derivatives regulate FGF19 in human enterocytes and which…
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Zitierempfehlung
D Jahn, D Sutor, HM Hermanns, J Schmitt, A Geier (2015) Retinoic acid amplifies the FXR-dependent FGF19 gene expression in human enterocyte-like HT-29 cells by a bi-phasic mechanism. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0034-1397147
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