CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras protooncogenes in mice
DOI 10.1055/s-0034-1397156
Bibliografische Angaben
Nachweis in CareLit
Autor:innenDF Calvisi, A Cigliano, C Wang, MG Pilo, M Sini, F Dombrowski, X Chen, M Evert
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Concomitant expression of activated forms of AKT and Ras in the mouse liver (AKT/Ras) leads to rapid tumor development via strong activation of the mTORC1 pathway. mTORC1 functions via regulating p70S6K/RPS6 and 4EBP1/eIF4E cascades. How these cascades contribute to hepatocarcinogenesis remains unknown. Here, we show that inhibition of RPS6 pathway via Rapamycin effectively suppressed, whereas blockade of the 4EBP1/…
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Zitierempfehlung
DF Calvisi, A Cigliano, C Wang, MG Pilo, M Sini, F Dombrowski, X Chen, M Evert (2015) 4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras protooncogenes in mice. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0034-1397156
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