CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Cooperative function of YAP and TAZ in hepatocytes and hepatocarcinogenesis
DOI 10.1055/s-0034-1397162
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Autor:innenT Lutz, S Weiler, F Pinna, S Wan, J Marquardt, H Lang, P Schirmacher, K Breuhahn
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: The Hippo pathway with its two downstream effectors, the transcriptional co-activators YAP (yes-associated protein) and TAZ (WW Domain Containing Transcription Regulator 1), is a central regulator of organ size. Inactivation of this pathway or overexpression of YAP has been demonstrated to induce hepatomegaly and liver cancer in mice. TAZ has been implicated in the regulation of epithelial-mesenchymal tr…
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Zitierempfehlung
T Lutz, S Weiler, F Pinna, S Wan, J Marquardt, H Lang, P Schirmacher, K Breuhahn (2015) Cooperative function of YAP and TAZ in hepatocytes and hepatocarcinogenesis. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0034-1397162
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