CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Inactivation of Cyclin E1 acts pro-apoptotic and anti-proliferative in primary hepatoma cells and protects from hepatocarcinogenesis in mice
DOI 10.1055/s-0034-1397175
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Nachweis in CareLit
Autor:innenN Moro, R Sonntag, YA Nevzorova, JM Bangen, D Fahrenkamp, D Lambertz, W Hu, N Gassler, G Müller-Newen, R Weiskirchen, M Barbacid, P Sicinski, C Trautwein, C Liedtke
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background & Aims: E-type cyclins (CcnE1, CcnE2) are regulatory subunits of Cyclin-dependent kinase 2 (Cdk2). There is evidence that CcnE/Cdk2 complexes control the transition of quiescent cells into the cell cycle. Surprisingly, genetic deletion of CcnE1, CcnE2 or Cdk2 does not inhibit cell proliferation during embryonic development or liver regeneration. The aim of the present study was to evaluate if E-type cycli…
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Zitierempfehlung
N Moro, R Sonntag, YA Nevzorova, JM Bangen, D Fahrenkamp, D Lambertz, W Hu, N Gassler, G Müller-Newen, R Weiskirchen, M Barbacid, P Sicinski, C Trautwein, C Liedtke (2015) Inactivation of Cyclin E1 acts pro-apoptotic and anti-proliferative in primary hepatoma cells and protects from hepatocarcinogenesis in mice. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0034-1397175
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