CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Inducing active demethylation through 5-Azacytidine open a new aspect for treatment of Hepatocellular Carcinoma
DOI 10.1055/s-0034-1397178
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Nachweis in CareLit
Autor:innenSO Sajadian, S Ehnert, A Bachmann, B Sipos, AK Nuessler
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Hepatocellular carcinoma (HCC) is the fifth deadliest cancer worldwide. Global deregulation of the methylation status is one of the main causes of HCC. The oxidation of 5-methylcytosine (5mC) triggers the formation of 5-hydroxymethylcytosine (5hmC). 5hmC can be depleted from the genome through down-regulation of the TET proteins leading to the demethylation of previously silenced genes. It has been repor…
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Zitierempfehlung
SO Sajadian, S Ehnert, A Bachmann, B Sipos, AK Nuessler (2015) Inducing active demethylation through 5-Azacytidine open a new aspect for treatment of Hepatocellular Carcinoma. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0034-1397178
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