CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Inhibition of canonical IKK/NF-kB signaling in Hepatitis B Virus surface antigen transgenic mice drastically increases HCC development due to dysregulated Unfolded Protein Response control
DOI 10.1055/s-0034-1397179
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Nachweis in CareLit
Autor:innenY Sunami, M Ringelhan, M Lu, N Hüser, E Kokai, F Leithäuser, J Kleeff, S Gul, S Wissel, D Hartmann, RM Schmid, H Friess, C Brunner, P Riedl, R Schirmbeck, P Strnad, M Heikenwälder, T Wirth
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and Aims: Hepatitis B Virus (HBV) remains the most common risk factor for hepatocellular carcinoma (HCC). It has been suggested that, in addition to chronic inflammation, HBV viral products directly contribute in HBV-driven hepatocellular carcinogenesis. In patients with low HBV replication, it is proposed that accumulation of HBV surface antigen (HBsAg) in the endoplasmic reticulum (ER) of hepatocytes (r…
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Zitierempfehlung
Y Sunami, M Ringelhan, M Lu, N Hüser, E Kokai, F Leithäuser, J Kleeff, S Gul, S Wissel, D Hartmann, RM Schmid, H Friess, C Brunner, P Riedl, R Schirmbeck, P Strnad, M Heikenwälder, T Wirth (2015) Inhibition of canonical IKK/NF-kB signaling in Hepatitis B Virus surface antigen transgenic mice drastically increases HCC development due to dysregulated Unfolded Protein Response control. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0034-1397179
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