CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
p53/telomerase-dependent oncolytic adenoviruses harboring a p53-dependent feed forward loop results in reduced viral liver burden
DOI 10.1055/s-0034-1397191
Bibliografische Angaben
Nachweis in CareLit
Autor:innenP Schirmer, E Gürlevik, M Saborowski, MP Manns, S Kubicka, F Kühnel
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Broad applicable vectors with highly selectivity and efficient lytic capabilities in tumors are essential for oncolytic virotherapy. Therefore, we developed selectively-replicating oncolytic viruses, which simultaneously target tumor cell-specific telomerase reexpression and p53-transcriptional deficiency, two molecular alterations which play a fundamental role in carcinogenesis and can therefore be frequently found…
Zitieren
Zitierempfehlung
P Schirmer, E Gürlevik, M Saborowski, MP Manns, S Kubicka, F Kühnel (2015) p53/telomerase-dependent oncolytic adenoviruses harboring a p53-dependent feed forward loop results in reduced viral liver burden. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0034-1397191
Mit CareLit weiterarbeiten