CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Relevance of organic cation transporter OCT1 (SLC22A1) in Diethylnitrosamine-initiated and Phenobarbital-promoted hepatocellular carcinoma in OCT3- knockout mice
DOI 10.1055/s-0034-1397195
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Nachweis in CareLit
Autor:innenJ Knapstein, P Fuchs, G Daniel, F Darstein, J Marquardt, M Sprinzl, J Schattenberg, MA Wörns, A Lautem, M Hoppe-Lotichius, H Lang, PR Galle, T Zimmermann
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Organic cation transporters (OCT) are responsible for the uptake and intracellular inactivation of a broad spectrum of endogenous substrates. OCTs became pharmaceutically interesting, because they are determinants of the cytotoxicity of platin derivates and the transport activity has been shown to correlate with the sensitivity of tumors towards tyrosine kinase inhibitors. Recent data have shown a down-r…
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Zitierempfehlung
J Knapstein, P Fuchs, G Daniel, F Darstein, J Marquardt, M Sprinzl, J Schattenberg, MA Wörns, A Lautem, M Hoppe-Lotichius, H Lang, PR Galle, T Zimmermann (2015) Relevance of organic cation transporter OCT1 (SLC22A1) in Diethylnitrosamine-initiated and Phenobarbital-promoted hepatocellular carcinoma in OCT3- knockout mice. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0034-1397195
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