CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Serum Reponse Factor (SRF) is a transcriptional activator of Mouse Double Minute 4 (MDM4) in hepatocellular carcinoma
DOI 10.1055/s-0034-1397198
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Nachweis in CareLit
Autor:innenR Pellegrino, A Thavamani, R Geffers, P Schirmacher, A Nordheim, T Longerich
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2015
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
The Mouse Double Minute 4 (MDM4) represents a p53-binding protein acting as a transcriptional repressor. We have previously demonstrated that both MDM4 mRNA and protein levels are upregulated in about 50% of human hepatocellular carcinomas (HCC). Although we identified 1q32 gains as a mechanism leading to MDM4 overexpression in human HCC, many liver tumors show a balanced MDM4 gene locus, but high MDM4 mRNA levels.…
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Zitierempfehlung
R Pellegrino, A Thavamani, R Geffers, P Schirmacher, A Nordheim, T Longerich (2015) Serum Reponse Factor (SRF) is a transcriptional activator of Mouse Double Minute 4 (MDM4) in hepatocellular carcinoma. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0034-1397198
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