CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Sp1 dependent transcriptional regulation of G-protein coupled bile acid receptor Gpbar-1: role of Krüppel like factor 5
DOI 10.1055/s-0034-1397201
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Autor:innenC Chinatalpati, C Wöhler, C Ehlting, J Bode, D Häussinger, V Keitel
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2015
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
TGR5 (Gpbar-1) is a G-protein coupled bile acid receptor, which is highly expressed in cholangiocytes, liver sinusoidal endothelial cells, liver macrophages and CD14 positive monocytes of peripheral blood. TGR5-/- mice show impaired liver regeneration after partial hepatectomy and the increased inflammation in liver disease models, thus emphasizing a protective role of TGR5 in liver. While TGR5 functions are being s…
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Zitierempfehlung
C Chinatalpati, C Wöhler, C Ehlting, J Bode, D Häussinger, V Keitel (2015) Sp1 dependent transcriptional regulation of G-protein coupled bile acid receptor Gpbar-1: role of Krüppel like factor 5. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0034-1397201
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