CareLit · DOI-Nachweis · Pneumologie
Specific siRNA targeting RORγt inhibits airway inflammation and airway hyperresponsiveness in a mouse model of neutrophilic asthma
DOI 10.1055/s-0035-1544604
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Autor:innenS Webering, L Lunding, H Fehrenbach, M Wegmann
ZeitschriftPneumologie
Ausgabe02/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Epidemiological studies suggest T helper 17 (Th17) cells as important players in the progression of asthma towards a severe phenotype. Regulated by the transcription factor Retinoic acid-related Orphan Receptor gamma (RORγ) t, which is essential for the effector functions and the differentiation and of these cells, Th17 cells appear to act as general promoters of chronic inflammatory responses. Objecti…
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Zitierempfehlung
S Webering, L Lunding, H Fehrenbach, M Wegmann (2015) Specific siRNA targeting RORγt inhibits airway inflammation and airway hyperresponsiveness in a mouse model of neutrophilic asthma. Pneumologie (02). https://doi.org/10.1055/s-0035-1544604
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