CareLit · DOI-Nachweis · Pneumologie
Pro-proliferative and inflammatory signaling converge on the FoxO1 transcription factor in pulmonary hypertension – a new therapeutic approach
DOI 10.1055/s-0035-1544772
Bibliografische Angaben
Nachweis in CareLit
Autor:innenR Savai, HM Al-Tamari, D Sedding, B Kojonazarov, C Muecke, R Teske, MR Capecchi, N Weissmann, F Grimminger, W Seeger, RT Schermuly, S Savai Pullamsetti
ZeitschriftPneumologie
Ausgabe02/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Pulmonary hypertension (PH) is characterized by increased proliferation and apoptosis resistance of pulmonary artery smooth muscle cells (PASMCs). Forkhead box O (FoxO) transcription factors are key regulators of cellular proliferation. Here we show that FoxO1 was downregulated (expression) and inactivated (phosphorylation, nuclear exclusion) in vessels/PASMCs of human and experimental PH lungs. This was reproduced…
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Zitierempfehlung
R Savai, HM Al-Tamari, D Sedding, B Kojonazarov, C Muecke, R Teske, MR Capecchi, N Weissmann, F Grimminger, W Seeger, RT Schermuly, S Savai Pullamsetti (2015) Pro-proliferative and inflammatory signaling converge on the FoxO1 transcription factor in pulmonary hypertension – a new therapeutic approach. Pneumologie (02). https://doi.org/10.1055/s-0035-1544772
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