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The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response

A Rabes, S Zimmermann, R Lang, K Reppe, PH Seeberger, N Suttorp, M Witzenrath, B Lepenies, B Opitz · Pneumologie · Ausgabe 04/2015

DOI 10.1055/s-0035-1548636

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Autor:innenA Rabes, S Zimmermann, R Lang, K Reppe, PH Seeberger, N Suttorp, M Witzenrath, B Lepenies, B Opitz
ZeitschriftPneumologie
Ausgabe04/2015
Jahrgang / SeitenNicht angegeben

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Introduction: The innate immune system employs C-type lectin receptors (CLRs) to recognize carbohydrate structures on pathogens and self-antigens. The Macrophage-inducible C-type lectin (Mincle) is a FcRγ-coupled CLR that was shown to bind to mycobacterial cord factor as well as certain fungal species. However, since CLR functions during bacterial infections have not yet been investigated thoroughly, we examined the…

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A Rabes, S Zimmermann, R Lang, K Reppe, PH Seeberger, N Suttorp, M Witzenrath, B Lepenies, B Opitz (2015) The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response. Pneumologie (04). https://doi.org/10.1055/s-0035-1548636

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