CareLit · DOI-Nachweis · Pneumologie
The increased protection and pathology in Mycobacterium tuberculosis-infected IL-27R-deficient mice is mediated by IL-17A
DOI 10.1055/s-0035-1548643
Bibliografische Angaben
Nachweis in CareLit
Autor:innenH Erdmann, C Hölscher, J Behrends
ZeitschriftPneumologie
Ausgabe04/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Einleitung: The IL-12 cytokine family member IL-27 has a broad inhibitory effect on Th1, Th2 and Th17 immune responses. With regard to Mycobacterium tuberculosis (Mtb) infection, we have previously shown that mice lacking the IL-27 receptor (IL-27R) have lower bacterial burdens in comparison to wildtype mice. However, IL-27R deficiency was associated with an accelerated death and an enhanced granulomatous response.…
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Zitierempfehlung
H Erdmann, C Hölscher, J Behrends (2015) The increased protection and pathology in Mycobacterium tuberculosis-infected IL-27R-deficient mice is mediated by IL-17A. Pneumologie (04). https://doi.org/10.1055/s-0035-1548643
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