CareLit · DOI-Nachweis · Pneumologie
Treatment of airway inflammation and airway hyperresponsiveness in a mouse model of neutrophilic asthma using a RORγt-specific siRNA
DOI 10.1055/s-0035-1548659
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Autor:innenS Webering, L Lunding, H Fehrenbach, M Wegmann
ZeitschriftPneumologie
Ausgabe04/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Studies suggest T helper 17 (Th17) cells as important players in the pathogenesis of neutrophilic asthma. Characterized by the production of pro-inflammatory cytokines like TNF-α, IL-1ß, IL-22 and IL-17A and the expression of the transcription factor Retinoic acid-related Orphan Receptor gamma (RORγ)t, Th17 cells appear to act as general promoters of chronic inflammatory responses. Thus, it is conceiva…
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Zitierempfehlung
S Webering, L Lunding, H Fehrenbach, M Wegmann (2015) Treatment of airway inflammation and airway hyperresponsiveness in a mouse model of neutrophilic asthma using a RORγt-specific siRNA. Pneumologie (04). https://doi.org/10.1055/s-0035-1548659
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