CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Podocyte-selective overexpression of the TGF-ß1 receptor type II (TbRII) enhances diabetic nephropathy in STZ induced transgenic rats
DOI 10.1055/s-0035-1549555
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Autor:innenT Micakovic, R Walz, HP Hammes, W Kriz, SC Hoffmann
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe04/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Glomerular TGF-ß1 is increased early in the course of diabetic nephropathy. The podocytes are sources and targets of TGF-ß1. This study addresses the hypothesis that increased TGF-ß1 in diabetic rats stimulates the development of diabetic nephropathy via selective signalling in podocytes. Methods: Transgenic rats carrying the TGRTßRII driven by the podocin promoter were generated. Transgene expression wa…
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Zitierempfehlung
T Micakovic, R Walz, HP Hammes, W Kriz, SC Hoffmann (2015) Podocyte-selective overexpression of the TGF-ß1 receptor type II (TbRII) enhances diabetic nephropathy in STZ induced transgenic rats. Diabetologie und Stoffwechsel (04). https://doi.org/10.1055/s-0035-1549555
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