CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
O-glycosyltransferase activation in leukocytes contributes to early renal function impairment in type 2 diabetes
DOI 10.1055/s-0035-1549586
Bibliografische Angaben
Nachweis in CareLit
Autor:innenK Kaul, C Koliaki, B Nowotny, R Rütter, B Menart, M Blumensatt, M Ouwens, M Roden
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe04/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Leukocytes infiltration into renal tissue is an early feature of diabetic kidney disease. Leukocyte homing and extravasation is influenced by O-glycosylation of serine and threonine rich proteins by enzyme Core 2 β-1, 6-N-acetylglucosaminyltransferase (Core-2). We hypothesized that hyperglycemia induces activation of Core-2 O-glycosylates adhesion molecule very late antigen-4 (VLA-4), thereby increasing adhesion and…
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Zitierempfehlung
K Kaul, C Koliaki, B Nowotny, R Rütter, B Menart, M Blumensatt, M Ouwens, M Roden (2015) O-glycosyltransferase activation in leukocytes contributes to early renal function impairment in type 2 diabetes. Diabetologie und Stoffwechsel (04). https://doi.org/10.1055/s-0035-1549586
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