CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Preserved insulin response of Nupr1-transgenic islets during diabetogenic injury is correlated with reduced secretion of IL-1beta and enhanced secretion of IL-1 receptor antagonist
DOI 10.1055/s-0035-1549755
Bibliografische Angaben
Nachweis in CareLit
Autor:innenAE Mehana, J Straetener, J Baumann, N Perakakis, K Laubner, J Seufert, G Päth
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe04/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: We previously demonstrated that transgenic mice with beta cell-specific overexpression of Nupr1 (Nupr1-Tg) are resistant to multiple low-dose streptozotocin (STZ) and/or high fat diet (HFD). Preserved insulin secretion of Nupr-Tg islets in vivo was associated with reduced NF-kB activation and less lymphocyte infiltration. The pro-inflammatory cytokine IL-1beta is well known to promote beta cell apoptos…
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Zitierempfehlung
AE Mehana, J Straetener, J Baumann, N Perakakis, K Laubner, J Seufert, G Päth (2015) Preserved insulin response of Nupr1-transgenic islets during diabetogenic injury is correlated with reduced secretion of IL-1beta and enhanced secretion of IL-1 receptor antagonist. Diabetologie und Stoffwechsel (04). https://doi.org/10.1055/s-0035-1549755
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