CareLit · DOI-Nachweis · Klinische Pädiatrie
Improved lentiviral CRISPR-Cas9 vectors for the generation of leukemogenic chromosomal translocations
DOI 10.1055/s-0035-1550233
Bibliografische Angaben
Nachweis in CareLit
Autor:innenJ Reimer, S Knoess, M Labuhn, JH Klusmann, D Heckl
ZeitschriftKlinische Pädiatrie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: AML subgroups are cytogenetically defined by recurrent chromosomal translocation (CTs), which are causative for leukemic transformation. CRISPR-Cas9-based genome editing emerged as a powerful tool for modelling CTs. However, broad application to primary hematopoietic stem and progenitor cells (HSPCs) was limited due to inefficient delivery tools. Methods: Here, we generated and evaluated improved lenti…
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Zitierempfehlung
J Reimer, S Knoess, M Labuhn, JH Klusmann, D Heckl (2015) Improved lentiviral CRISPR-Cas9 vectors for the generation of leukemogenic chromosomal translocations. Klinische Pädiatrie (07). https://doi.org/10.1055/s-0035-1550233
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