CareLit · DOI-Nachweis · Klinische Pädiatrie
Long-term imatinib treatment reduces spermatogenic cell proliferation in juvenile rat testes
DOI 10.1055/s-0035-1550235
Bibliografische Angaben
Nachweis in CareLit
Autor:innenV Girke, JT Tauer, M Suttorp
ZeitschriftKlinische Pädiatrie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Long-term tyrosine kinase inhibitor (TKI) “targeted” treatment in pediatric patients with chronic myeloic leukemia reveals multiple off-target side effects. Specifically in testes, TKIs signaling cascades necessary for spermatogenesis are inhibited but the detailed action is not yet fully understood. Therefore, we investigated testicular tissue under TKI exposure in a juvenile rat model. Methods: Growing…
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Zitierempfehlung
V Girke, JT Tauer, M Suttorp (2015) Long-term imatinib treatment reduces spermatogenic cell proliferation in juvenile rat testes. Klinische Pädiatrie (07). https://doi.org/10.1055/s-0035-1550235
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