CareLit · DOI-Nachweis · Klinische Pädiatrie
Investigating the functional interplay of IRX1 and IRX2 homeoprotein family members and MLL fusion proteins
DOI 10.1055/s-0035-1550240
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Autor:innenA Kühn, E Kowarz, R Marschalek
ZeitschriftKlinische Pädiatrie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The Iroquois 1 (IRX1) gene has been identified as a candidate gene that is strongly upregulated in t(4;11) leukemia patients which display a transcriptional downregulation of HOXA genes, a phenomenon that was associated even with a worse outcome (Trentin et al., 2009; Stam et al., 2010.). Here we present our cummulated data about Iroquois 1 and 2, both influencing the transcriptional properties of different key play…
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Zitierempfehlung
A Kühn, E Kowarz, R Marschalek (2015) Investigating the functional interplay of IRX1 and IRX2 homeoprotein family members and MLL fusion proteins. Klinische Pädiatrie (07). https://doi.org/10.1055/s-0035-1550240
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