CareLit · DOI-Nachweis · Klinische Pädiatrie
Investigating the long-term and genome-wide effects of the AF4-MLL fusion protein
DOI 10.1055/s-0035-1550241
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Nachweis in CareLit
Autor:innenD Löscher, E Kowarz, R Marschalek
ZeitschriftKlinische Pädiatrie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The oncoprotein AF4-MLL has been shown to induce proB ALL in a murine model system, by using retroviral gene transfer into murine LSK cells and subsequent transplanation experiments into lethally irradiated mice. Leukemia development took about 6.5 month (Bursen et al., 2010). We also affinity-purified the AF4-MLL fusion protein complex and demonstrated its aberrant functions in vitro (hyperactive P-TEFb kinase, inc…
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Zitierempfehlung
D Löscher, E Kowarz, R Marschalek (2015) Investigating the long-term and genome-wide effects of the AF4-MLL fusion protein. Klinische Pädiatrie (07). https://doi.org/10.1055/s-0035-1550241
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