CareLit · DOI-Nachweis · Klinische Pädiatrie
Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wildtype MLL
DOI 10.1055/s-0035-1550242
Bibliografische Angaben
Nachweis in CareLit
Autor:innenK Ahmad, C Katryniok, B Scholz, J Merkens, R Marschalek, D Steinhilber
ZeitschriftKlinische Pädiatrie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The ALOX5 gene encodes 5-lipoxygenase (5-LO), a key enzyme of inflammatory reactions. 5-LO expression is induced by VitD3 and/or TGFβ and transcription initiation was associated with an increase in histone H3 lysine 4 trimethylation (H3K4me3) in a TSA-inducible fashion. Therefore, we investigated the effects of the MLL protein and its derivatives, MLL-AF4 and AF4-MLL, respectively. MLL-AF4 was able to enhance ALOX5…
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Zitierempfehlung
K Ahmad, C Katryniok, B Scholz, J Merkens, R Marschalek, D Steinhilber (2015) Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wildtype MLL. Klinische Pädiatrie (07). https://doi.org/10.1055/s-0035-1550242
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