CareLit · DOI-Nachweis · Klinische Pädiatrie
Stability of DNA methylation signatures in a long-term murine xenograft system of juvenile myelomonocytic leukemia
DOI 10.1055/s-0035-1550252
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Nachweis in CareLit
Autor:innenCF Krombholz, A Meier, S Fluhr, CM Niemeyer, M Erlacher, C Flotho
ZeitschriftKlinische Pädiatrie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative disorder of early childhood that is resistant to conventional cancer therapies. Aggressive cases are characterized by specific DNA hypermethylation. Methods: Rag2-/- γc-/- mice were xenotransplanted with primary mononuclear cells from JMML patients. Methylation arrays (Illumina 450K) were used to compare DNA methylation patterns in source…
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Zitierempfehlung
CF Krombholz, A Meier, S Fluhr, CM Niemeyer, M Erlacher, C Flotho (2015) Stability of DNA methylation signatures in a long-term murine xenograft system of juvenile myelomonocytic leukemia. Klinische Pädiatrie (07). https://doi.org/10.1055/s-0035-1550252
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