CareLit · DOI-Nachweis · Klinische Pädiatrie
Synthetic diblock copolymer micelles as vectors for siRNA delivery to knockdown RUNX1/ETO in acute myeloid leukaemia cells
DOI 10.1055/s-0035-1550253
Bibliografische Angaben
Nachweis in CareLit
Autor:innenD Coleman, D Fulton, O Heidenreich
ZeitschriftKlinische Pädiatrie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Knockdown of RUNX1/ETO using short interfering ribonucleic acids (siRNAs) in vitro has been shown to inhibit acute myeloid leukaemia (AML) cell growth and proliferation. Due to the poor pharmacokinetic properties of siRNA a delivery system is required for therapeutic use in vivo. We propose a polymeric nanoparticle (PNP) system consisting of two diblock copolymers which can be targeted to acute myeloid leukaemia cel…
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Zitierempfehlung
D Coleman, D Fulton, O Heidenreich (2015) Synthetic diblock copolymer micelles as vectors for siRNA delivery to knockdown RUNX1/ETO in acute myeloid leukaemia cells. Klinische Pädiatrie (07). https://doi.org/10.1055/s-0035-1550253
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