CareLit · DOI-Nachweis · Klinische Pädiatrie
Identification of compounds protecting donor stem cells from apoptosis and increasing efficacy of hematopoietic stem cell transplantation
DOI 10.1055/s-0035-1550256
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Kollek, G Voigt, D Bertele, A Garcia, F Krombholz, N Fischer, C Niemeyer, S Geley, M Erlacher
ZeitschriftKlinische Pädiatrie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
HSCT is the only curative treatment for many hematological and immunological diseases but is hampered by the risk of graft failure or delayed engraftment. In previous studies we have identified two Bcl-2 proteins from the pro-apoptotic BH3-only subgroup, Bim and Bmf, to be central players in apoptosis induction of hematopoietic stem and progenitor cells (HSPCs) during transplantation. Permanent inhibition of either…
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Zitierempfehlung
M Kollek, G Voigt, D Bertele, A Garcia, F Krombholz, N Fischer, C Niemeyer, S Geley, M Erlacher (2015) Identification of compounds protecting donor stem cells from apoptosis and increasing efficacy of hematopoietic stem cell transplantation. Klinische Pädiatrie (07). https://doi.org/10.1055/s-0035-1550256
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