CareLit · DOI-Nachweis · Klinische Pädiatrie
What we learned from bench to bedside with the neuroblastoma targeting CD171-specific CAR
DOI 10.1055/s-0035-1550266
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Künkele, AJ Johnson, C Berger, L Finn, J Park, MC Jensen
ZeitschriftKlinische Pädiatrie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Despite efficacy of chimeric antigen receptor (CAR) T cell therapy in leukemia and lymphoma patients, similar clinical responses in solid tumor patients is an unrealized objective. We developed a CAR specific for CD171, an antigen expressed in several solid tumors including neuroblastoma. Methods: Since CD171 is also expressed in healthy tissues, we performed a safety study in non-human primates. Furth…
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Zitierempfehlung
A Künkele, AJ Johnson, C Berger, L Finn, J Park, MC Jensen (2015) What we learned from bench to bedside with the neuroblastoma targeting CD171-specific CAR. Klinische Pädiatrie (07). https://doi.org/10.1055/s-0035-1550266
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