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Immune composition of peripheral blood and responsiveness to Toll-like receptor (TLR) ligands at Day 29 of induction chemotherapy for pediatric acute lymphoblastic leukemia (ALL)

N Rolf, A Kariminia, KK Smolen, GS Reid · Klinische Pädiatrie · Ausgabe 07/2015

DOI 10.1055/s-0035-1550267

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Autor:innenN Rolf, A Kariminia, KK Smolen, GS Reid
ZeitschriftKlinische Pädiatrie
Ausgabe07/2015
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Introduction: Although ALL has long been viewed as a poor target for immune therapy, peripheral blood (PB) absolute lymphocyte count (ALC) at end of induction chemotherapy (Day 29) seems to be prognostic for outcome. However, whether ALC is simply a marker of bone marrow recovery or whether certain immune cell subsets confer a beneficial effect is unknown. Methods: We collected D29 PB and i) performed an extensive p…

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N Rolf, A Kariminia, KK Smolen, GS Reid (2015) Immune composition of peripheral blood and responsiveness to Toll-like receptor (TLR) ligands at Day 29 of induction chemotherapy for pediatric acute lymphoblastic leukemia (ALL). Klinische Pädiatrie (07). https://doi.org/10.1055/s-0035-1550267

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