CareLit · DOI-Nachweis · Senologie - Zeitschrift für Mammadiagnostik und -therapie
EZH2 is overexpressed in breast tumors with a BRCA1-like DNA copy number profile
DOI 10.1055/s-0035-1550556
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Autor:innenJ Puppe, M Opdam, P Schouten, P Mallmann, S Rodenhuis, M Hauptmann, R Schmutzler, S Linn, J Jonkers
ZeitschriftSenologie - Zeitschrift für Mammadiagnostik und -therapie
Ausgabe05/2015
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Purpose: The polycomb group protein EZH2 is an epigenetic repressor through its trimethylase activity of H3K27me3 and overexpression of EZH2 is associated with aggressive types of breast cancer. We previously reported that breast tumors deriving from a BRCA1-deficient mouse model show high levels of EZH2. Human BRCA1-mutated breast tumors carry a specific DNA copy-number signature („BRCA1-like“) which is also found…
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Zitierempfehlung
J Puppe, M Opdam, P Schouten, P Mallmann, S Rodenhuis, M Hauptmann, R Schmutzler, S Linn, J Jonkers (2015) EZH2 is overexpressed in breast tumors with a BRCA1-like DNA copy number profile. Senologie - Zeitschrift für Mammadiagnostik und -therapie (05). https://doi.org/10.1055/s-0035-1550556
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