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Iron (III)-Sodium-EDTA, as used for food fortification, aggravates intestinal inflammation and drives tumorigenesis in mouse models of colitis-associated cancer

R Evstatiev, T Austerlitz, V Khare, K Jimenez, S Klimscha, M Lang, A Krnjic, C Gasche · Zeitschrift für Gastroenterologie · Ausgabe 05/2015

DOI 10.1055/s-0035-1551691

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Autor:innenR Evstatiev, T Austerlitz, V Khare, K Jimenez, S Klimscha, M Lang, A Krnjic, C Gasche
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe05/2015
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Western lifestyle is associated with increasing prevalence of IBD, processed food and food fortification being a likely cause. Iron supplementation may increase gut inflammation and colitis-associated cancer (CAC). Novel Fe products which are chemically not Fe(II) salts and presumably better tolerated have become available. Here we compared various Fe compounds at 450 mg elemental Fe/kg chow [Na-EDTA-Fe(III) (as use…

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R Evstatiev, T Austerlitz, V Khare, K Jimenez, S Klimscha, M Lang, A Krnjic, C Gasche (2015) Iron (III)-Sodium-EDTA, as used for food fortification, aggravates intestinal inflammation and drives tumorigenesis in mouse models of colitis-associated cancer. Zeitschrift für Gastroenterologie (05). https://doi.org/10.1055/s-0035-1551691

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