CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Inhibition of intestinal bile acid absorption by ASBT inhibitor A4250 protects against cholestatic liver and bile duct injury in MDR2-/- mouse model of sclerosing Cholangitis
DOI 10.1055/s-0035-1551767
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Nachweis in CareLit
Autor:innenCD Fuchs, A Baghdasaryan, CH Österreicher, U Lemberger, H Graffner, E Krones, P Fickert, A Wahlström, H Marschall, G Paumgartner, M Trauner
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe05/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and Aims: Approximately 95% of bile acids (BAs) excreted into bile are reabsorbed in the gut and circulate back to the liver for further biliary secretion. Therefore, pharmacological inhibition of the ileal apical sodium-dependent BA transporter (ASBT/SLC10A2) may protect against BA-mediated cholestatic liver and bile duct injury. Methods: 8-week-old Mdr2-/- (Abcb4-/-) mice (model of cholestatic liver inj…
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Zitierempfehlung
CD Fuchs, A Baghdasaryan, CH Österreicher, U Lemberger, H Graffner, E Krones, P Fickert, A Wahlström, H Marschall, G Paumgartner, M Trauner (2015) Inhibition of intestinal bile acid absorption by ASBT inhibitor A4250 protects against cholestatic liver and bile duct injury in MDR2-/- mouse model of sclerosing Cholangitis. Zeitschrift für Gastroenterologie (05). https://doi.org/10.1055/s-0035-1551767
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