CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Absence of BSEP/ABCB11 protects from cholestatic liver and bile duct injury in a mouse model of sclerosing Cholangitis
DOI 10.1055/s-0035-1551778
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Autor:innenCD Fuchs, G Paumgartner, A Wahlström, T Stojakovic, H Marschall, M Trauner
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe05/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Cholestasis leads to liver injury reflected by disruption of hepatocellular integrity, inflammation and fibrosis. Bile salt export pump (BSEP/ABCB11) is the main canalicular BA transporter and therefore rate limiting step for hepatobiliary BA secretion. Here we investigate the role of ABCB11 in development of cholestatic liver and bile duct injury in a model of sclerosing cholangitis. WT and ABCB11KO mice were subje…
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Zitierempfehlung
CD Fuchs, G Paumgartner, A Wahlström, T Stojakovic, H Marschall, M Trauner (2015) Absence of BSEP/ABCB11 protects from cholestatic liver and bile duct injury in a mouse model of sclerosing Cholangitis. Zeitschrift für Gastroenterologie (05). https://doi.org/10.1055/s-0035-1551778
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