Notch ligands stimulate immune regulatory mechanism of inflammatory cells in PAH

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Besides vasoconstriction and in situ thrombosis, “vascular remodelling” is a key feature of pulmonary arterial hypertension (PAH). This process is comprised of cellular hypertrophy, cell proliferation in the intima and media of vessels involved. An increased accumulation of T- and B-lymphocytes as well as of macrophages was observed in plexiform lesions and in the remodelled artery walls. Furthermore, elevated level…

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