CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Adenoviral Vector Designed for p53 Dependent Transgene Expression and Replication as a Potential Tool for Cancer Gene Therapy
DOI 10.1055/s-0035-1555194
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Nachweis in CareLit
Autor:innenF Kühnel, L Zender, T Wirth, B Schulte, MP Manns, S Kubicka
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe05/2015
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: A major obstacle of adenoviral gene therapy of cancer is the restriction of therapeutic gene expression or viral replication to malignant cells to avoid severe side effects on healthy tissue. In this study we present the bicistronic adenoviral vector Adp53dpR for gene therapy of cancer cells with altered p53-status. Methods/Results: Initially a luciferase reporter version of Adp53dpR was constructed. One…
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Zitierempfehlung
F Kühnel, L Zender, T Wirth, B Schulte, MP Manns, S Kubicka (2015) Adenoviral Vector Designed for p53 Dependent Transgene Expression and Replication as a Potential Tool for Cancer Gene Therapy. Zeitschrift für Gastroenterologie (05). https://doi.org/10.1055/s-0035-1555194
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